Starring: David Letterman Paul Shaffer David Letterman Creator: Eric Stangel Episodes S22 E1: Luke Wilson, Julie Chen, Lee Brice S22 E2: Kristen Wiig, Sen. Elizabeth Warren, The New Pornographers S22 E3: Steve Buscemi, Indy Car Season Champ, Alt-J S22 E4: Tina Fey, Moody McCarthy, Kevin Drew S22 E5: Bill Maher, Henrik Lundqvist, Spoon S22 E6: Michael Strahan, Richard Branson, Interpol S22 E7: Dr. Phil, Katharine McPhee, Death from Above 1979, Ray Benson S22 E8: Jason Bateman, Billy Eichner, Ryan Adams S22 E9: Mindy Kaling, Jake Johannsen, Maddie & Tae S22 E10: Mark Harmon, "Jungle" Jack Hanna S22 E11: Denzel Washington, Lenny Kravitz S22 E12: Kelly Ripa, Jim Gaffigan, Paloma Faith S22 E13: Jerry Seinfeld, Michael Jackson ONE S22 E14: Ted Danson, Andrew Norelli S22 E15: Neil Patrick Harris, Jamie Oliver, Aretha Franklin S22 E16: John Oliver, Maggie Q, Bleachers S22 E17: Bill O'Reilly, Cristin Milioti S22 E18: Johnny Galecki, Andre Benjamin, Delta Spirit S22 E19: Mariska Hargitay, Simon Amstell, Kandace Springs S22 E20: Aziz Ansari, Tom Dreesen S22 E21: Robert Downey Jr., Sarah Paulson, Lizzo S22 E22: Anderson Cooper, Gina Rodriguez, Hatsune Miku S22 E23: Robert Duvall, Elle Fanning, Rival Sons S22 E24: Chelsea Handler; Keegan-Michael Key and Jordan Peele; Angaleena Presley S22 E25: Russell Brand, Dave Grohl, Foo Fighters S22 E26: Michael Keaton, Foo Fighters S22 E27: Bill Murray, Foo Fighters S22 E28: Tom Selleck, Jenny Slate, Foo Fighters S22 E29: Jessica Chastain, Lenny Marcus, Foo Fighters S22 E30: Amy Poehler, Sen. Jeff Flake, Sen. Martin Heinrich, Mastodon, Jerry Lee Lewis S22 E31: Taylor Swift, Tom Mison S22 E32: Jim Carrey, David Tennant S22 E33: Brian Williams, Perfume Genius S22 E34: Keith Olbermann, Brian Regan, Run the Jewels S22 E35: Martin Short, Father John Misty S22 E36: Jennifer Lopez, Rob Riggle, Kimbra S22 E37: Whoopi Goldberg, Jimmy Page, Mapei S22 E38: Amy Schumer, Jeff Caldwell S22 E39: Katie Holmes, Alex Zanardi S22 E40: Steve Carell, Martha Stewart, OK Go S22 E41: Jennifer Lawrence, Boris Johnson S22 E42: Jon Stewart, Shawn Mendes S22 E43: Kristin Chenoweth; Chris Young S22 E44: Jason Sudeikis, Allison Janney, Damien Rice S22 E45: Stupid Pet Tricks, Charlie Day, Hiss Golden Messenger S22 E46: Regis Philbin, Hundred Waters S22 E47: Edward Norton, Jessye Norman S22 E48: Norman Lear, TV on the Radio S22 E49: Seth Rogen, Amy Sedaris S22 E50: Emily Blunt, Adam Resnick, Wu-Tang Clan S22 E51: Jake Gyllenhaal, Dr. John P. Holdren, Nico & Vinz S22 E52: Joaquin Phoenix, Cristela Alonzo, Al Green S22 E53: Ben Stiller, Olivia Munn, LaLa Brooks S22 E54: Meryl Streep, Rebel Wilson, J. Cole S22 E55: Chris Rock, Sting S22 E56: Jamie Foxx, Robert Klein, Dan Penn S22 E57: Emma Stone Top, Marcus Mariota, Bob Seger S22 E58: New Holiday Toys, Anna Kendrick, Charli XCX S22 E59: Tom Brokaw, Will Nelson & Billy Joe Shaver S22 E60: Rosie O’Donnel,l Jeff Altman S22 E61: Jay Thomas, Josh Brolin, Darlene Love S22 E62: Kathy Griffin, David Oyelowo, Lera Lynn S22 E63: Ethan Hawke, Allison Williams, Parquet Courts S22 E64: Julianne Moore, Catfish & the Bottlemen S22 E65: Donald Trump, Chelsea Peretti, Foxygen S22 E66: Michael Somerville, Nicole Atkins S22 E67: Gordon Ramsay, Adam Devine, St. Paul and the Broken Bones S22 E68: Anderson Cooper, Shovels & Rope S22 E69: Amanda Peet, Ryn Weaver S22 E70: Larry David, Dan Patrick, Sleater-Kinney S22 E71: Urban Meyer, Johnny Beehner, Ella Henderson S22 E72: Louis CK, Nicolle Wallace, the Lone Bellow S22 E73: Andrew Luck, Oscar Isaac, Drenge S22 E74: Viola Davis, Ben Schwartz, Marty Stuart S22 E75: John Oliver, Mayim Bialik, Death Cab for Cutie S22 E76: Aziz Ansari, Brian Kiley, Ben Howard S22 E77: Jack Hanna, Sharon Jones and the Dap-Kings S22 E78: Dr. Phil McGraw, Robin Tunney, Diana Krall S22 E79: Ryan Reynolds, Dierks Bentley S22 E80: Martin Short, Bettye Lavette S22 E81: Sienna Miller, Andy Kindler, Bob Mould S22 E82: Steve Carell, Dr. Cornel West S22 E83: Courtney Love, Chris Elliott, Rhiannon Giddens S22 E84: Bill Belichick, Elisabeth Moss, Madisen Ward and the Mama Bear S22 E85: Tom Hanks, Sturgill Simpson S22 E86: Bill Hader, Pat McGann, Shakey Graves S22 E87: Matthew Perry, Adam Scott, Kishi Bashi S22 E88: Dakota Johnson, David Tochinskiy, Twin Shadow S22 E89: Will Smith, Grizfolk S22 E90: Don Cheadle, Ilana Glazer & Abbi Jacobson, Mikky Ekko S22 E91: Kid Scientists, Sean Hayes, Judah & the Lion S22 E92: Helen Mirren, the 2015 Daytona 500 winner, Steve Earle S22 E93: Matthew Broderick, Ellie Kemper, JD McPherson S22 E94: Julianna Margulies, Eric Ripert, Glass Animals S22 E95: Kevin Spacey, Lily James, Alabama Shakes S22 E96: Patricia Arquette, Will Butler S22 E97: Kelsey Grammer, Stevie Wonder S22 E98: Lena Dunham, Bobby Cannavale, Andy Kim with Kevin Drew S22 E99: Kevin Bacon, Jimmie Walker, Airborne Toxic Event S22 E100: Shailene Woodley, Dr. Cornel West, Matthew E. White S22 E101: Will Ferrell, Glen Hansard S22 E102: Norm MacDonald, Theo James S22 E103: Ben Stiller, Tove Lo S22 E104: Bill O'Reilly, Aubrey Plaza S22 E105: James Franco, Jake Johannsen, Action Bronson S22 E106: Neil Patrick Harris, Charlie Cox, the Suffers S22 E107: David Duchovny, Josh Gad, Houndmouth S22 E108: Sen. Al Franken, Billy Eichner, David Sanborn S22 E109: Kelly Ripa, Aasif Mandvi, Fat White Family S22 E110: Mike Myers, Nick Griffin, Banks S22 E111: Sarah Jessica Parker, Julie Chen, Asleep at the Wheel S22 E112: Billy Crystal, Chris Russo, Chris Stapleton S22 E113: Michael J. Fox, Iron & Wine, Ben Bridwell S22 E114: Kevin James, Tom Dreesen, Tracy Chapman S22 E115: Alec Baldwin, John Mayer S22 E116: John Travolta, Amy Schumer, the Waterboys S22 E117: Piedmont Bird Callers, Paul Rudd S22 E118: Bruce Willis, Dawes S22 E119: Robert Downey Jr., Chris Russo, Elvis Costello S22 E120: Jerry Seinfeld, Jason Isbell & Amanda Shires S22 E121: Scarlett Johansson, John Mellencamp, Todd Rundgren S22 E122: Michael Keaton, Future Islands S22 E123: Jack Hanna, John Popper S22 E124: First Lady Michelle Obama Hootie and the Blowfish S22 E125: Steve Martin, Emmylou Harris, Rodney Crowell, Amos Lee, Ralph Stanley, Mark O'Connor S22 E126: President Barack Obama, Will Ferrell, the Avett Brothers, Brandi Carlile S22 E127: Reese Witherspoon, Nathan Lane, Mumford & Sons S22 E128: Martin Short, Norah Jones S22 E129: Tina Fey, First Aid Kit S22 E130: Ray Romano, Brian Regan, Dave Matthews Band S22 E131: Howard Stern, Don Rickles S22 E132: Bill Clinton, Adam Sandler S22 E133: Julia Roberts, Paul Shaffer, Ryan Adams S22 E134: Al Pacino, George Clooney, Tom Waits S22 E135: Oprah Winfrey, Norm Macdonald S22 E136: Tom Hanks, Eddie Vedder S22 E137: Bill Murray, Bob Dylan S22 E138: The Final Late Show with David Letterman S22 E139: President Barack Obama/Will Ferrell/Brandi Carlile & the Avett Brothers S22 E140: Reese Witherspoon/Nathan Lane/Mumford & Sons S22 E141: Martin Short/Norah Jones S22 E142: Tina Fey/First Aid Kit S22 E143: Ray Romano/Brian Regan/Dave Matthews Band S22 E144: Howard Stern/Don Rickles S22 E145: Bill Clinton/Adam Sandler S22 E146: Julia Roberts/Paul Shaffer/Ryan Adams S22 E147: George Clooney/Tom Waits S22 E148: Oprah Winfrey/Norm McDonald S22 E149: S22 E150: Bill Murray/Bob Dylan S22 E151: The Final Late Show with David Letterman